Ca2+ increases in the heart control both contraction and transcription. To accommodate a short-term increased cardiovascular demand, neurohormonal modulators acting on the cardiac pacemaker and individual myocytes induce an increase in frequency and magnitude of myocyte contraction respectively. Prolonged, enhanced function results in hypertrophic growth of the heart, which is initially also associated with greater Ca2+ signals and cardiac contraction. As a result of disease, however, hypertrophy progresses to a decompensated state and Ca2+ signalling capacity and cardiac output are reduced. Here, the role that Ca2+ plays in the induction of hypertrophy as well as the impact that cardiac hypertrophy and failure has on Ca2+ fluxes will be discussed.
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November 2007
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Conference Article|
October 25 2007
Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid
H.L. Roderick;
H.L. Roderick
1
*Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, U.K.
†Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K.
1To whom correspondence should be addressed (email Llewelyn.roderick@bbsrc.ac.uk).
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D.R. Higazi;
D.R. Higazi
†Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K.
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I. Smyrnias;
I. Smyrnias
†Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K.
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C. Fearnley;
C. Fearnley
†Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K.
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D. Harzheim;
D. Harzheim
†Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K.
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M.D. Bootman
M.D. Bootman
†Laboratory of Molecular Signalling, Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB22 3AT, U.K.
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Publisher: Portland Press Ltd
Received:
June 18 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (5): 957–961.
Article history
Received:
June 18 2007
Citation
H.L. Roderick, D.R. Higazi, I. Smyrnias, C. Fearnley, D. Harzheim, M.D. Bootman; Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid. Biochem Soc Trans 1 November 2007; 35 (5): 957–961. doi: https://doi.org/10.1042/BST0350957
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