This paper presents the BioShuttle platform as a delivery vehicle for transfer of contrast agents and genetic material into target cells, which can be followed by activation of the BioShuttle inside the target cell. Here, we present a transporter system and summarize the findings on transporter use in vivo and in vitro. The results here are limited to examples where cargoes (drugs, genetically active materials or contrast agents) are covalently associated with the transporter module. A further example, in which the cargo is non-covalently attached to the BioShuttle, is also discussed. Finally, attempts have been made to solve some of the issues surrounding the efficiency of transfer of therapeutic or diagnostic agents and their later activity in the cell.
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August 2007
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Conference Article|
July 20 2007
Generation, application and quantification of clamp–BioShuttle carriers for plasmid delivery into nuclei of prostate cancer cells
R. Pipkorn;
R. Pipkorn
1
*Central Section for Peptide Synthesis, German Cancer Research Center, INF 580, D-69120 Heidelberg, Germany
1To whom correspondence should be addressed (email r.pipkorn@dkfz.de).
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W. Waldeck;
W. Waldeck
†Division of Biophysics of Macromolecules, German Cancer Research Center, INF 580, D-69120 Heidelberg, Germany
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J.W. Jenne;
J.W. Jenne
‡Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, INF 280, D-69120 Heidelberg, Germany
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B. Didinger;
B. Didinger
§Radiation Oncology, University of Heidelberg, INF 400, D-69120 Heidelberg, Germany
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K. Braun
K. Braun
∥Division of Molecular Toxicology, German Cancer Research Center, INF 280, D-69120 Heidelberg, Germany
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Publisher: Portland Press Ltd
Received:
May 10 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (4): 829–832.
Article history
Received:
May 10 2007
Citation
R. Pipkorn, W. Waldeck, J.W. Jenne, B. Didinger, K. Braun; Generation, application and quantification of clamp–BioShuttle carriers for plasmid delivery into nuclei of prostate cancer cells. Biochem Soc Trans 1 August 2007; 35 (4): 829–832. doi: https://doi.org/10.1042/BST0350829
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