Each normal organ and pathological condition contains organ- or disease-specific molecular tags on its vasculature that constitute a vascular ‘zip code’ system. Tissue-selective tumour metastasis may also depend on vascular addresses. We have used phage display peptide libraries to map disease-specific differences in the vasculature. By using this technology, we have isolated several peptides which are targeted specifically to tumour blood vessels, lymphatic vessels and/or tumour cells. Some of the tumour-homing peptides recognize common angiogenesis markers and are capable of binding to several types of tumour, whereas other peptides recognize tumour-type-specific differences. We have also shown that the vasculature of a pre-malignant lesion differs from that of a full-blown tumour and also from the vasculature of the corresponding normal organ. Our peptides have revealed molecules that act as novel biomarkers of this vascular heterogeneity. Interestingly, some of our homing peptides are able to penetrate the target cells. This internalization differs from that of the Tat, penetratins and other related peptides in that our peptides enter the cell in a cell-type-specific manner. These peptides appear to be able to concentrate in the target tissue, making them particularly efficient delivery vectors for the targeting of drugs, other therapeutic moieties and imaging agents.
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August 2007
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Conference Article|
July 20 2007
Tumour-homing peptides: tools for targeting, imaging and destruction
J. Enbäck;
J. Enbäck
1Molecular Cancer Biology Research Program and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Finland
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P. Laakkonen
P. Laakkonen
1
1Molecular Cancer Biology Research Program and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Finland
1To whom correspondence should be addressed (email pirjo.laakkonen@helsinki.fi).
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Publisher: Portland Press Ltd
Received:
April 23 2007
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem Soc Trans (2007) 35 (4): 780–783.
Article history
Received:
April 23 2007
Citation
J. Enbäck, P. Laakkonen; Tumour-homing peptides: tools for targeting, imaging and destruction. Biochem Soc Trans 1 August 2007; 35 (4): 780–783. doi: https://doi.org/10.1042/BST0350780
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