Statins inhibit the dimerization of β-secretase [BACE (β-site amyloid precursor protein-cleaving enzyme)] by inhibiting the lipidation of BACE and associated proteins. Our studies have demonstrated a clearly defined temporal sequence for these reactions in the assembly of the BACE complex, which may provide targets for the treatment of Alzheimer's disease.

Keywords:
amyloid β-peptide, β-site amyloid precursor protein-cleaving enzyme (BACE), cholesterol, farnesylation, palmitoylation, β-secretase
© 2007 Biochemical Society
2007
You do not currently have access to this content.