The class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first identified as a regulator of vacuolar hydrolase sorting in yeast. Unlike other PI3Ks, the Vps34 lipid kinase specifically utilizes phosphatidylinositol as a substrate, producing the single lipid product PtdIns3P. While Vps34 has been studied for some time in the context of endocytosis and vesicular trafficking, it has more recently been implicated as an important regulator of autophagy, trimeric G-protein signalling, and the mTOR (mammalian target of rapamycin) nutrient-sensing pathway. The present paper will focus on studies that describe the regulation of hVps34 (human Vps34) intracellular targeting and enzymatic activity in yeast and mammalian cells.
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April 2007
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Conference Article|
March 20 2007
Regulation of class III (Vps34) PI3Ks
Y. Yan;
Y. Yan
1Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, U.S.A.
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J.M. Backer
J.M. Backer
1
1Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, U.S.A.
1To whom correspondence should be addressed (email Backer@aecom.yu.edu).
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Publisher: Portland Press Ltd
Received:
November 01 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 The Biochemical Society
2007
Biochem Soc Trans (2007) 35 (2): 239–241.
Article history
Received:
November 01 2006
Citation
Y. Yan, J.M. Backer; Regulation of class III (Vps34) PI3Ks. Biochem Soc Trans 1 April 2007; 35 (2): 239–241. doi: https://doi.org/10.1042/BST0350239
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