PKB (protein kinase B, also known as Akt) is a serine/threonine protein kinase that is important in various signalling cascades and acts as a major signal transducer downstream of activated phosphoinositide 3-kinase. There are three closely related isoforms of PKB in mammalian cells, PKBα (Akt1), PKBβ (Akt2) and PKBγ (Akt3), and this review discusses recent advances in our understanding of the functions of these isoforms in the regulation of adipocyte differentiation, glucose homoeostasis and tumour development.

Keywords:
adipocyte differentiation, cancer, glucose homoeostasis, mouse model, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), protein kinase B (PKB)
© 2007 The Biochemical Society
2007
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