ES (embryonic stem) cell lines are derived from the epiblast of pre-implantation embryos and like the inner cell mass cells from which they are derived exhibit the remarkable property of pluripotency, namely the ability to differentiate into all cell lineages comprising the adult organism. ES cells and their differentiated progeny offer tremendous potential to regenerative medicine, particularly as cellular therapies for the treatment of a wide variety of chronic disorders, such as Type 1 diabetes, Parkinson's disease and retinal degeneration. In order for this potential to be realized, a detailed understanding of the molecular mechanisms regulating the fundamental properties of ES cells, i.e. pluripotency, proliferation and differentiation, is required. In the present paper, we review the evidence that PI3K (phosphoinositide 3-kinase)-dependent signalling plays a role in regulation of both ES cell pluripotency and proliferation.
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April 2007
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Conference Article|
March 20 2007
Phosphoinositide 3-kinases and regulation of embryonic stem cell fate
M.J. Welham;
M.J. Welham
1
1Department of Pharmacy and Pharmacology and The Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
1To whom correspondence should be addressed (email prsmjw@bath.ac.uk).
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M.P. Storm;
M.P. Storm
1Department of Pharmacy and Pharmacology and The Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
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E. Kingham;
E. Kingham
1Department of Pharmacy and Pharmacology and The Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
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H.K. Bone
H.K. Bone
1Department of Pharmacy and Pharmacology and The Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, U.K.
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Publisher: Portland Press Ltd
Received:
November 22 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2007 The Biochemical Society
2007
Biochem Soc Trans (2007) 35 (2): 225–228.
Article history
Received:
November 22 2006
Citation
M.J. Welham, M.P. Storm, E. Kingham, H.K. Bone; Phosphoinositide 3-kinases and regulation of embryonic stem cell fate. Biochem Soc Trans 1 April 2007; 35 (2): 225–228. doi: https://doi.org/10.1042/BST0350225
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