Many stressful, but not lethal, stimuli activate endogenous protective mechanisms that significantly decrease the degree of injury to subsequent injurious stimuli. This protective mechanism is termed preconditioning and tolerance. It occurs across organ systems including the brain and nervous system. Preconditioning has been investigated in cell and animal models and recently been shown to potentially occur in human brain. Learning more about these powerful endogenous neuroprotective mechanisms could help identify new approaches to treat patients with stroke and other central nervous system disorders or injury. Cell and animal models are helping us to better understand the network response of gene and protein expression that activates the neuroprotective response.
Skip Nav Destination
Article navigation
December 2006
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 25 2006
Mining for survival genes
V.L. Dawson;
V.L. Dawson
1
*Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
†Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
‡Department of Neuroscience, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
§Department of Physiology, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
1To whom correspondence should be addressed, at Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 711, Baltimore, MD 21205, U.S.A. (email vdawson@jhmi.edu).
Search for other works by this author on:
T.M. Dawson
T.M. Dawson
*Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
†Department of Neurology, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
‡Department of Neuroscience, Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 22 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1307–1309.
Article history
Received:
July 22 2006
Citation
V.L. Dawson, T.M. Dawson; Mining for survival genes. Biochem Soc Trans 1 December 2006; 34 (6): 1307–1309. doi: https://doi.org/10.1042/BST0341307
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.