IL-1O (interleukin-10) negatively regulates inflammation through a mechanism that blocks the expression of pro-inflammatory genes encoding cytokines, chemokines, cell-surface molecules and other molecules required for the full activation of the innate and adaptive immune responses. The signalling pathway used by the IL-10 receptor to generate the anti-inflammatory response requires STAT3 (signal transducer and activator of transcription 3) and is indirect. Thus STAT3 activates other genes whose task is to selectively control transcription of inflammatory targets. Here, I summarize current knowledge of the key features of IL-10 signalling and make predictions concerning the mechanism of IL-10 at the level of inflammatory genes. Understanding IL-10 signalling should be a gateway to the development of broadly acting anti-inflammatory agents.
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December 2006
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Conference Article|
October 25 2006
STAT3-mediated anti-inflammatory signalling
P.J. Murray
P.J. Murray
1
1Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, U.S.A.
1email Peter.murray@stjude.org
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Publisher: Portland Press Ltd
Received:
June 23 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1028–1031.
Article history
Received:
June 23 2006
Citation
P.J. Murray; STAT3-mediated anti-inflammatory signalling. Biochem Soc Trans 1 December 2006; 34 (6): 1028–1031. doi: https://doi.org/10.1042/BST0341028
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