Chemokines play a key role in directing and driving leucocyte trafficking. The efficient regulation of leucocyte recruitment by chemokines requires their appropriate localization in functional micro-anatomical domains, as well as setting limits to their effects in space and time. Both processes are influenced by silent chemokine receptors (interceptors), including DARC (Duffy antigen receptor for chemokines). Increasing experimental evidence suggests that DARC is involved in accumulation of extravascular chemokines in endothelial cells, chemokine transcytosis and presentation on their luminal surface, leading to leucocyte adhesion and emigration. Additionally, DARC is expressed on erythrocytes and can act as a sink for chemokines in blood. This limits the dissemination of chemokines through blood into distant organs and tissues as well as reducing their effects on the circulating leucocytes.
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December 2006
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Conference Article|
October 25 2006
Throwing light on DARC
M. Pruenster;
M. Pruenster
1Novartis Institutes for BioMedical Research, Brunnerstr. 59, A-1230 Vienna, Austria
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A. Rot
A. Rot
1
1Novartis Institutes for BioMedical Research, Brunnerstr. 59, A-1230 Vienna, Austria
1To whom correspondence should be addressed (email antal.rot@novartis.com).
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Publisher: Portland Press Ltd
Received:
June 27 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (6): 1005–1008.
Article history
Received:
June 27 2006
Citation
M. Pruenster, A. Rot; Throwing light on DARC. Biochem Soc Trans 1 December 2006; 34 (6): 1005–1008. doi: https://doi.org/10.1042/BST0341005
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