mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that play an important neuromodulatory role in the brain. Glutamatergic transmission itself plays a fundamental role in the simple nervous system of the model organism Caenorhabditis elegans, but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl-1, mgl-2 and mgl-3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls. Our results indicate that mgl genes constitute a gene family made up of three distinct subclasses of receptor. Our transcript analysis highlights potential for complex gene regulation with respect to both expression and splicing. Further, we identify that the predicted proteins encoded by mgls harbour structural motifs that are likely to regulate function. Taken together, this molecular characterization provides a platform to further investigate mGluR function in the model organism C. elegans.
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October 2006
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Conference Article|
October 25 2006
Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans
J. Dillon;
J. Dillon
1School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, Hants. SO16 7PX, U.K.
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N.A. Hopper;
N.A. Hopper
1School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, Hants. SO16 7PX, U.K.
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L. Holden-Dye;
L. Holden-Dye
1School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, Hants. SO16 7PX, U.K.
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V. O'Connor
V. O'Connor
1
1School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, Hants. SO16 7PX, U.K.
1To whom correspondence should be addressed (email voconno@soton.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 14 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (5): 942–948.
Article history
Received:
August 14 2006
Citation
J. Dillon, N.A. Hopper, L. Holden-Dye, V. O'Connor; Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans. Biochem Soc Trans 1 October 2006; 34 (5): 942–948. doi: https://doi.org/10.1042/BST0340942
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