By comparison with other species, the meiotic process in the human female is extraordinarily error-prone. In addition to the well-known effect of advancing maternal age, recent studies have demonstrated that the number and location of meiotic recombination events influences the likelihood of meiotic non-disjunction in our species. Although this association extends to many other organisms, the factors that influence the number and placement of exchanges within a cell remain poorly understood. Like other aspects of meiosis, the control of recombination is likely to be subject to variation among species. In this review we summarize data from recent studies in mammals; the combined data suggest that both genetic and environmental factors influence recombination in mammals and, importantly, that control mechanisms probably differ between males and females.
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Conference Article|
July 21 2006
Meiosis in mammals: recombination, non-disjunction and the environment
P.A. Hunt
P.A. Hunt
1
1School of Molecular Biosciences and Center for Reproduction, Fulmer Hall 539, Washington State University, P.O. Box 644660, Pullman, WA 99164-4660, U.S.A.
1email pathunt@wsu.edu
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Publisher: Portland Press Ltd
Received:
March 16 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (4): 574–577.
Article history
Received:
March 16 2006
Citation
P.A. Hunt; Meiosis in mammals: recombination, non-disjunction and the environment. Biochem Soc Trans 1 August 2006; 34 (4): 574–577. doi: https://doi.org/10.1042/BST0340574
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