The cAMP pathway is of cardinal importance for heart physiology and pathology. The spatial organization of the various components of the cAMP pathway is thought to allow the segregation of functional responses triggered by the different neuromediators and hormones that use this pathway. PDEs (phosphodiesterases) hydrolyse cAMP (and cGMP) and play a major role in this process by preventing cAMP diffusion to the whole cytosol and inadequate target activation. The development of olfactory cyclic nucleotide-gated channels to directly monitor cAMP beneath the plasma membrane in real time allows us to gain new insights into the molecular mechanisms responsible for cAMP homoeostasis and hormonal specificity in cardiac cells. The present review summarizes the recent results we obtained using this approach in adult rat ventricular myocytes. In particular, the role of PDEs in the maintenance of specific cAMP signals generated by β-adrenergic receptors and other Gs-coupled receptors will be discussed.
Skip Nav Destination
Article navigation
August 2006
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
July 21 2006
Functional localization of cAMP signalling in cardiac myocytes
G. Vandecasteele;
G. Vandecasteele
1
1INSERM U769, Faculté de Pharmacie, Université de Paris-Sud 11, Châtenay-Malabry, France
1To whom correspondence should be addressed, at INSERM, U769, Faculté de Pharmacie, Université de Paris-Sud, 5, Rue J.-B. Clément, F-92296 Châtenay-Malabry Cedex, France (email gregoire.vandecasteele@cep.u-psud.fr).
Search for other works by this author on:
F. Rochais;
F. Rochais
1INSERM U769, Faculté de Pharmacie, Université de Paris-Sud 11, Châtenay-Malabry, France
Search for other works by this author on:
A. Abi-Gerges;
A. Abi-Gerges
1INSERM U769, Faculté de Pharmacie, Université de Paris-Sud 11, Châtenay-Malabry, France
Search for other works by this author on:
R. Fischmeister
R. Fischmeister
1INSERM U769, Faculté de Pharmacie, Université de Paris-Sud 11, Châtenay-Malabry, France
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 03 2006
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (4): 484–488.
Article history
Received:
April 03 2006
Citation
G. Vandecasteele, F. Rochais, A. Abi-Gerges, R. Fischmeister; Functional localization of cAMP signalling in cardiac myocytes. Biochem Soc Trans 1 August 2006; 34 (4): 484–488. doi: https://doi.org/10.1042/BST0340484
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.