Scaffolding proteins create order out of chaos. Multifunctional binding proteins such as the AKAPs (A-kinase-anchoring proteins) oversee the dynamic organization of signalling events by clustering activator proteins with kinases, phosphatases and phosphodiesterases and directing them toward their downstream effectors. This article will focus on the role of AKAPs in the spatial and temporal control of cAMP signalling events.

Keywords:
A-kinase-anchoring protein (AKAP), cAMP cycling, compartmentalization, protein kinase A (PKA)
© 2006 The Biochemical Society
2006
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