The endoplasmic reticulum is traditionally perceived as the key compartment for regulating intracellular cholesterol metabolism. Increasing evidence suggests that the endocytic pathway provides an additional regulatory level governing intracellular cholesterol trafficking and homoeostasis. Sterols can enter, and apparently also exit, endosomal compartments via both vesicular and non-vesicular mechanisms. A number of studies have focused on endosomal sterol removal as its defects lead to cholesterol storage diseases. So far, the bulk of evidence on endosomal sterol egress describes the involvement of membrane trafficking machineries. Interestingly, two late endosomal sterol-binding proteins were recently shown to regulate the movement of late endosomes along cytoskeletal tracks. These studies provide the first indications of how non-vesicular and vesicular mechanisms may co-operate in endosomal sterol trafficking.
Skip Nav Destination
Article navigation
June 2006
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
May 22 2006
Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet
M. Hölttä-Vuori;
M. Hölttä-Vuori
1Institute of Biomedicine/Anatomy, Haartmaninkatu 8, P.O. Box 63, 00014 University of Helsinki, Finland
Search for other works by this author on:
E. Ikonen
E. Ikonen
1
1Institute of Biomedicine/Anatomy, Haartmaninkatu 8, P.O. Box 63, 00014 University of Helsinki, Finland
1To whom correspondence should be addressed (email elina.ikonen@helsinki.fi).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
December 20 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (3): 392–394.
Article history
Received:
December 20 2005
Citation
M. Hölttä-Vuori, E. Ikonen; Endosomal cholesterol traffic: vesicular and non-vesicular mechanisms meet. Biochem Soc Trans 1 June 2006; 34 (3): 392–394. doi: https://doi.org/10.1042/BST0340392
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.