Yeast Sec14p acts as a phosphatidylinositol/phosphatidylcholine-transfer protein in vitro. In vivo, it is essential in promoting Golgi secretory function. Products of five genes named SFH1–SFH5 (Sec Fourteen Homologues 1–5) exhibit significant sequence homology to Sec14p and together they form the Sec14p family of lipid-transfer proteins. It is a diverse group of proteins with distinct subcellular localizations and varied physiological functions related to lipid metabolism and membrane trafficking.

Keywords:
Golgi secretion, lipid metabolism, phosphatidylcholine, phosphatidylinositol-transfer protein, Sec14 homologue, yeast
© 2006 The Biochemical Society
2006
You do not currently have access to this content.