Antimicrobial peptides are fundamental effector molecules of innate immunity, utilized in host defence by virtually all organisms studied. These gene-encoded peptides have direct antibiotic activity against a wide range of bacteria and other microbes. In humans and other mammals, defensins are a predominant class of such peptides. In the mammalian small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce defensins and other antibiotic proteins. Recent investigations in murine models provide compelling support for the hypothesis that enteric defensins play a pivotal role in defence from food- and water-borne pathogens in the intestinal lumen. Investigations by others indicate that intestinal commensal bacteria are key factors in the pathogenesis of IBD (inflammatory bowel disease) in genetically susceptible humans. Recent studies provide evidence that reduced expression of Paneth cell defensins may be a key factor in the pathogenesis of ileal Crohn's disease, a subgroup of IBD. Future studies to further define the function and regulation of Paneth cell defensins will enhance our understanding of normal small bowel physiology, and probably contribute to a better understanding of the pathogenesis of inflammatory and infectious diseases of the bowel. Such knowledge may provide new therapeutic targets and strategies.
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April 2006
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Conference Article|
March 20 2006
Paneth cell defensins: key effector molecules of innate immunity
C.L. Bevins
C.L. Bevins
1
1Department of Medical Microbiology and Immunology, University of California School of Medicine, One Shields Avenue, Tupper Hall, Rm. 3146, Davis, CA 95616, U.S.A.
1email CLBevins@ucdavis.edu
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Publisher: Portland Press Ltd
Received:
November 25 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (2): 263–266.
Article history
Received:
November 25 2005
Citation
C.L. Bevins; Paneth cell defensins: key effector molecules of innate immunity. Biochem Soc Trans 1 April 2006; 34 (2): 263–266. doi: https://doi.org/10.1042/BST0340263
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