Upon cell-cycle arrest or nutrient deprivation, the cellular rate of ribosome production is reduced significantly. In mammalian cells, this effect is achieved in part through a co-ordinated inhibition of RP (ribosomal protein) synthesis. More specifically, translation initiation on RP mRNAs is inhibited. Translational regulation of RP synthesis is dependent on cis-elements within the 5′-UTRs (5′-untranslated regions) of the RP mRNAs. In particular, a highly conserved 5′-TOP (5′-terminal oligopyrimidine tract) appears to play a key role in the regulation of RP mRNA translation. This article explores recent developments in our understanding of the mechanism of TOP mRNA regulation, focusing on upstream signalling pathways and trans-acting factors, and highlighting some interesting observations which have come to light following the recent development of cDNA microarray technology coupled with polysome analysis.
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February 2006
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Conference Article|
January 20 2006
TOPs and their regulation
T.L. Hamilton;
T.L. Hamilton
1
1School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K.
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M. Stoneley;
M. Stoneley
1
1School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K.
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K.A. Spriggs;
K.A. Spriggs
1School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K.
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M. Bushell
M. Bushell
2
1School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K.
2 To whom correspondence should be addressed (email Martin.Bushell@nottingham.ac.uk).
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Publisher: Portland Press Ltd
Received:
August 15 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2006 The Biochemical Society
2006
Biochem Soc Trans (2006) 34 (1): 12–16.
Article history
Received:
August 15 2005
Citation
T.L. Hamilton, M. Stoneley, K.A. Spriggs, M. Bushell; TOPs and their regulation. Biochem Soc Trans 1 February 2006; 34 (1): 12–16. doi: https://doi.org/10.1042/BST0340012
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