Overcoming DNA replication fork blocks is essential for completing genome duplication and cell division. Archaea and eukaryotes drive replication using essentially the same protein machinery. Archaea may be a valuable resource for identifying new helicase components at advancing forks and/or in replication-restart pathways. As described here, these may be relevant to understanding genome instability in metazoans.

Keywords:
archaea, DNA repair, Hel308, helicase, replication fork, replication restart
© 2005 The Biochemical Society
2005
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