Amines are a carbon source for the growth of a number of bacterial species and they also play key roles in neurotransmission, cell growth and differentiation, and neoplastic cell proliferation. Enzymes have evolved to catalyse these reactions and these oxidoreductases can be grouped into the flavoprotein and quinoprotein families. The mechanism of amine oxidation catalysed by the quinoprotein amine oxidases is understood reasonably well and occurs through the formation of enzyme–substrate covalent adducts with TPQ (topaquinone), TTQ (tryptophan tryptophylquinone), CTQ (cysteine tryptophylquinone) and LTQ (lysine tyrosyl quinone) redox centres. Oxidation of amines by flavoenzymes is less well understood. The role of protein-based radicals and flavin semiquinone radicals in the oxidation of amines is discussed.
Skip Nav Destination
Article navigation
August 2005
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
August 01 2005
Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals
S.E. Rigby;
S.E. Rigby
*Department of Biological Sciences, Queen Mary College, University of London, London E1 4NS, U.K.
Search for other works by this author on:
J. Basran;
J. Basran
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
J.P. Combe;
J.P. Combe
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
A.W. Mohsen;
A.W. Mohsen
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
H. Toogood;
H. Toogood
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
A. van Thiel;
A. van Thiel
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
M.J. Sutcliffe;
M.J. Sutcliffe
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
D. Leys;
D. Leys
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
A.W. Munro;
A.W. Munro
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
Search for other works by this author on:
N.S. Scrutton
N.S. Scrutton
1
†Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, U.K.
1To whom correspondence should be addressed (email nss4@le.ac.uk).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 15 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 754–757.
Article history
Received:
March 15 2005
Citation
S.E. Rigby, J. Basran, J.P. Combe, A.W. Mohsen, H. Toogood, A. van Thiel, M.J. Sutcliffe, D. Leys, A.W. Munro, N.S. Scrutton; Flavoenzyme catalysed oxidation of amines: roles for flavin and protein-based radicals. Biochem Soc Trans 1 August 2005; 33 (4): 754–757. doi: https://doi.org/10.1042/BST0330754
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.