The gene DMBT1 (deleted in malignant brain tumour-1) has been proposed to play a role in brain and epithelial cancer, but shows unusual features for a classical tumour-suppressor gene. On the one hand, DMBT1 has been linked to mucosal protection, whereas, on the other, it potentially plays a role in epithelial differentiation. Thus its function in a particular tissue is of mechanistic importance for its role in cancer. Because the former function requires secretion to the lumen and the latter function may depend on its presence in the extracellular matrix, we decided to investigate DMBT1 expression, location and its mode of secretion during malignant transformation in colorectal cancer. Using human colorectal PC/AA cell lines and tissue sections from individual patients, we have examined the expression of DMBT1 and its glycosylation in the adenoma–carcinoma sequence leading to the adenocarcinoma phenotype.
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August 2005
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Conference Article|
August 01 2005
DMBT1 expression and glycosylation during the adenoma–carcinoma sequence in colorectal cancer
C. Robbe;
C. Robbe
*Mucin Research Group, Clinical Science at South Bristol, Bristol BS2 8HW, U.K.
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C. Paraskeva;
C. Paraskeva
†Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, U.K.
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J. Mollenhauer;
J. Mollenhauer
‡Deutscheskrebsforschungszentrum, 69120 Heidelberg, Germany
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J.C. Michalski;
J.C. Michalski
§Université des Sciences et Technologies de Lille 1, 59655 Villeneuve d'Ascq, France
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C. Sergi;
C. Sergi
†Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, U.K.
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A. Corfield
A. Corfield
1
*Mucin Research Group, Clinical Science at South Bristol, Bristol BS2 8HW, U.K.
1To whom correspondence should be addressed (email tony.corfield@bristol.ac.uk).
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Publisher: Portland Press Ltd
Received:
March 31 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 730–732.
Article history
Received:
March 31 2005
Citation
C. Robbe, C. Paraskeva, J. Mollenhauer, J.C. Michalski, C. Sergi, A. Corfield; DMBT1 expression and glycosylation during the adenoma–carcinoma sequence in colorectal cancer. Biochem Soc Trans 1 August 2005; 33 (4): 730–732. doi: https://doi.org/10.1042/BST0330730
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