Rab proteins are members of the superfamily of Ras-like small GTPases and are involved in several cellular processes relating to membrane trafficking and organelle mobility throughout the cell. Like other small GTPases, Rab proteins are initially synthesized as soluble proteins and for membrane attachment they require the addition of lipid moiety(ies) to specific residues of their polypeptide chain. Despite their well-documented roles in regulating cellular trafficking, Rab proteins own trafficking is still poorly understood. We still need to elucidate the molecular mechanisms of their recruitment to cellular membranes and the structural determinants for their specific cellular localization. Recent results indicate that Rab cellular targeting might be Rab-dependent, and this paper briefly reviews our current knowledge of this process.
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August 2005
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Conference Article|
August 01 2005
Targeting of Rab GTPases to cellular membranes
B.R. Ali;
B.R. Ali
1Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, U.K.
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M.C. Seabra
M.C. Seabra
1
1Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London SW7 2AZ, U.K.
1To whom correspondence should be addressed (email m.seabra@imperial.ac.uk).
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Publisher: Portland Press Ltd
Received:
May 17 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 652–656.
Article history
Received:
May 17 2005
Citation
B.R. Ali, M.C. Seabra; Targeting of Rab GTPases to cellular membranes. Biochem Soc Trans 1 August 2005; 33 (4): 652–656. doi: https://doi.org/10.1042/BST0330652
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