The YIP1 family comprises an evolutionarily conserved group of membrane proteins, which share the ability to bind di-prenylated Rab proteins. The biochemical capability of YIP1 family proteins suggests a possible role in the cycle of physical localization of Rab proteins between their cognate membranes and the cytosol. YIP1 is essential for viability in yeast and a deletion of YIP1 can be rescued with the human homologue YIP1A. We have made use of this evolutionary conservation of function to generate a series of mutant alleles of YIP1 to investigate the biological role of Yip1p. Our findings indicate evidence for the participation of Yip1p in both Rab and COPII protein function; at present, we are not able to distinguish between the models that these roles represent, i.e. independent or dependent activities of Yip1p.
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Conference Article|
August 01 2005
Insights into biological functions across species: examining the role of Rab proteins in YIP1 family function
C.Z. Chen;
C.Z. Chen
*Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, U.S.A.
†Graduate Program in Pharmacology, Cornell University, Ithaca, NY 14853, U.S.A.
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R.N. Collins
R.N. Collins
1
*Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, U.S.A.
1To whom correspondence should be addressed (email rnc8@cornell.edu).
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Publisher: Portland Press Ltd
Received:
March 09 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 614–618.
Article history
Received:
March 09 2005
Citation
C.Z. Chen, R.N. Collins; Insights into biological functions across species: examining the role of Rab proteins in YIP1 family function. Biochem Soc Trans 1 August 2005; 33 (4): 614–618. doi: https://doi.org/10.1042/BST0330614
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