Developments in molecular neuropathology have led to protein-based classification systems for neurodegenerative disorders. Key proteins include α-synuclein, amyloid and tau. Alternative mRNA splicing and post-translational change, induced by a bewildering variety of protein modifying processes such as phosphorylation and ubiquitination, have generated insights into new mechanisms of selective neuronal degeneration. The task now is to bring these developments in protein chemistry to the clinic, to try to determine whether this biochemical diversity can help in explaining the phenotypic variability that is so typical of neurodegeneration in general. In this review, we will explore the clinicopathological diversity of the tau-related disorders with specific reference to three of the most common tauopathies, frontotemporal dementia (familial and sporadic), progressive supranuclear palsy and corticobasal degeneration.
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Conference Article|
August 01 2005
Clinicopathological features of the tauopathies
B. Murray;
B. Murray
1
*Department of Neurology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland
†The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
1To whom correspondence should be addressed (email nevrob@iol.ie).
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T. Lynch;
T. Lynch
*Department of Neurology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland
†The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
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M. Farrell
M. Farrell
‡Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland
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Publisher: Portland Press Ltd
Received:
March 22 2005
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (4): 595–599.
Article history
Received:
March 22 2005
Citation
B. Murray, T. Lynch, M. Farrell; Clinicopathological features of the tauopathies. Biochem Soc Trans 1 August 2005; 33 (4): 595–599. doi: https://doi.org/10.1042/BST0330595
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