The transmembrane glycoprotein TF (tissue factor) plays an essential role in haemostasis as the principal initiator of blood coagulation. In this paper, we describe how the circulating blood cells – monocytes, platelets, neutrophils and their microparticles – co-operate in regulating the expression, availability and activity of monocyte-derived TF.

Keywords:
blood cell interaction, coagulation, microparticle, monocyte, platelet, tissue factor
© 2005 The Biochemical Society
2005
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