The concentrative nucleoside transporter (CNT) family (SLC28) has three members: SLC28A1 (CNT1), SLC28A2 (CNT2) and SLC28A3 (CNT3). The CNT1 and CNT2 transporters are co-expressed in liver parenchymal cells and macrophages, two suitable models in which to study cell cycle progression. Despite initial observations suggesting that these transporter proteins might contribute to nucleoside salvage during proliferation, their subcellular localization and regulatory properties suggest alternative roles in cell physiology. In particular, CNT2 is a suitable candidate for modulation of purinergic responses, since it is under the control of the adenosine 1 receptor. Increasing evidence also suggests a role for CNT2 in energy metabolism, since its activation relies on the opening of ATP-sensitive K+ channels. Animal and cell models genetically modified to alter nucleoside transporter expression levels may help to elucidate the particular roles of CNT proteins in cell physiology.
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February 2005
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Conference Article|
February 01 2005
The concentrative nucleoside transporter family (SLC28): new roles beyond salvage?
I. Aymerich;
I. Aymerich
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
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S. Duflot;
S. Duflot
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
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S. Fernández-Veledo;
S. Fernández-Veledo
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
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E. Guillén-Gómez;
E. Guillén-Gómez
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
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I. Huber-Ruano;
I. Huber-Ruano
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
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F.J. Casado;
F.J. Casado
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
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M. Pastor-Anglada
M. Pastor-Anglada
1
1Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08071 Barcelona, Spain
1To whom correspondence should be addressed (email mpastor@ub.edu).
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Publisher: Portland Press Ltd
Received:
September 28 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (1): 216–219.
Article history
Received:
September 28 2004
Citation
I. Aymerich, S. Duflot, S. Fernández-Veledo, E. Guillén-Gómez, I. Huber-Ruano, F.J. Casado, M. Pastor-Anglada; The concentrative nucleoside transporter family (SLC28): new roles beyond salvage?. Biochem Soc Trans 1 February 2005; 33 (1): 216–219. doi: https://doi.org/10.1042/BST0330216
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