Campylobacter jejuni is a small genome pathogen that is incapable of growing strictly anaerobically due to its dependence on an oxygen-requiring ribonucleotide reductase for DNA synthesis. Nevertheless, it has a complex branched respiratory chain, which allows the use of several alternative electron acceptors for growth under oxygen-limited conditions. C. jejuni is equipped with both nitrate reductase (Nap) and nitrite reductase (Nrf) located in the periplasm, each predicted to receive electrons from menaquinol through distinct redox proteins. The pathways of electron transport to nitrate and nitrite are reviewed in this paper. Nitrate is considered as a potential in vivo electron acceptor and a role for nitrite reductase in NO detoxification is suggested.
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Conference Article|
February 01 2005
Electron transport through nitrate and nitrite reductases in Campylobacter jejuni
M.S. Pittman;
M.S. Pittman
1Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K.
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D.J. Kelly
D.J. Kelly
1
1Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K.
1To whom correspondence should be addressed (email d.kelly@sheffield.ac.uk).
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Publisher: Portland Press Ltd
Received:
September 03 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2005 The Biochemical Society
2005
Biochem Soc Trans (2005) 33 (1): 190–192.
Article history
Received:
September 03 2004
Citation
M.S. Pittman, D.J. Kelly; Electron transport through nitrate and nitrite reductases in Campylobacter jejuni. Biochem Soc Trans 1 February 2005; 33 (1): 190–192. doi: https://doi.org/10.1042/BST0330190
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