The simplistic idea that seven transmembrane receptors are single monomeric proteins that interact with heterotrimeric G-proteins after agonist binding is definitively out of date. Indeed, GPCRs (G-protein-coupled receptors) are part of multiprotein networks organized around scaffolding proteins. These GIPs (GPCR-interacting proteins) are either transmembrane or cytosolic proteins. Proteomic approaches can be used to get global pictures of these ‘receptosomes’. This approach allowed us to identify direct but also indirect binding partners of serotonin receptors. GIPs are involved in a wide range of functions including control of the targeting, trafficking and signalling of GPCRs. One of them, Shank, which is a secondary and tertiary partner of metabotropic and ionotropic glutamate receptors, respectively, can induce the formation of a whole functional glutamate ‘receptosome’ and the structure to which it is associated, the dendritic spine.
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November 2004
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Conference Article|
October 26 2004
GPCR-interacting proteins (GIPs): nature and functions
J. Bockaert;
J. Bockaert
1
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
1To whom correspondence should be addressed (email joel.bockaert@ccipe.cnrs.fr).
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G. Roussignol;
G. Roussignol
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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C. Bécamel;
C. Bécamel
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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S. Gavarini;
S. Gavarini
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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L. Joubert;
L. Joubert
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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A. Dumuis;
A. Dumuis
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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L. Fagni;
L. Fagni
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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P. Marin
P. Marin
1LGF, UPR CNRS 2580, 141 rue de la Cardonille, 34094 Montpellier, Cedex 5, France
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Publisher: Portland Press Ltd
Received:
June 14 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (5): 851–855.
Article history
Received:
June 14 2004
Citation
J. Bockaert, G. Roussignol, C. Bécamel, S. Gavarini, L. Joubert, A. Dumuis, L. Fagni, P. Marin; GPCR-interacting proteins (GIPs): nature and functions. Biochem Soc Trans 1 November 2004; 32 (5): 851–855. doi: https://doi.org/10.1042/BST0320851
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