Integrins are adhesion receptors capable of transmitting intracellular signals that regulate many different cellular functions. Among integrin-mediated signals, the activation of ion channels can be included. We demonstrated that a long-lasting activation of hERG (human ether-a-go-go-related gene) potassium channels occurs in both human neuroblastoma and leukaemia cells after the activation of the β1 integrin subunit. This activation is apparently a determining factor inducing neurite extension and osteoclastic differentiation in both the cell types. More recently, we provided evidences that β1 integrins and hERG channels co-precipitate in both the cell types. Preliminary results suggest that a macromolecular signalling complex indeed occurs between integrins and the hERG1 protein and that hERG channel activity can modulate integrin downstream signalling.
Skip Nav Destination
Article navigation
November 2004
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
October 26 2004
Physical and functional interaction between integrins and hERG potassium channels
A. Arcangeli;
A. Arcangeli
1
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
1To whom correspondence should be addressed (email annarosa.arcangeli@unifi.it).
Search for other works by this author on:
A. Becchetti;
A. Becchetti
†Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza delle Scienze, 2, Milano, Italy
Search for other works by this author on:
A. Cherubini;
A. Cherubini
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
Search for other works by this author on:
O. Crociani;
O. Crociani
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
Search for other works by this author on:
P. Defilippi;
P. Defilippi
‡Department of Genetics, Biochemistry and Biology, University of Torino, Via Santena 5bis, Torino, Italy
Search for other works by this author on:
L. Guasti;
L. Guasti
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
Search for other works by this author on:
G. Hofmann;
G. Hofmann
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
Search for other works by this author on:
S. Pillozzi;
S. Pillozzi
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
Search for other works by this author on:
M. Olivotto;
M. Olivotto
*Department of Experimental Pathology and Oncology, University of Firenze, Italy
Search for other works by this author on:
E. Wanke
E. Wanke
†Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza delle Scienze, 2, Milano, Italy
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
July 05 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (5): 826–827.
Article history
Received:
July 05 2004
Citation
A. Arcangeli, A. Becchetti, A. Cherubini, O. Crociani, P. Defilippi, L. Guasti, G. Hofmann, S. Pillozzi, M. Olivotto, E. Wanke; Physical and functional interaction between integrins and hERG potassium channels. Biochem Soc Trans 1 November 2004; 32 (5): 826–827. doi: https://doi.org/10.1042/BST0320826
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.