One of the earliest hallmarks that distinguish growing axons from dendrites is their growth rate; axons grow faster than dendrites. In vertebrates, where axons are required to grow for considerable distances, particularly in the peripheral nervous system, a fast axon growth rate is a requisite property. In neurons that respond to the neurotrophin growth factor/nerve growth factor with increased axon growth rates, two distinct intracellular signalling pathways are recruited: the MAPK (mitogen-activated protein kinase) pathway and the phosphatidylinositol-3 kinase pathway. The activation of either pathway leads to changes in microtubule dynamics within growing axons and growth cones and these underlie fast axon growth rates. Microtubule dynamics is regulated by microtubule-associated proteins and in the MAPK pathway this function is subserved by microtubule-associated protein 1B, whereas in the phosphatidylinositol-3 kinase pathway, adenomatous polyposis coli is the regulating microtubule-associated protein.
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November 2004
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Conference Article|
October 26 2004
Glycogen synthase kinase 3β and the regulation of axon growth
R.G. Goold;
R.G. Goold
1The MRC Centre for Developmental Neurobiology, Guy's Campus, King's College London, London, U.K.
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P.R. Gordon-Weeks
P.R. Gordon-Weeks
1
1The MRC Centre for Developmental Neurobiology, Guy's Campus, King's College London, London, U.K.
1To whom correspondence should be addressed (email phillip.gordon-weeks@kcl.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 23 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (5): 809–811.
Article history
Received:
July 23 2004
Citation
R.G. Goold, P.R. Gordon-Weeks; Glycogen synthase kinase 3β and the regulation of axon growth. Biochem Soc Trans 1 November 2004; 32 (5): 809–811. doi: https://doi.org/10.1042/BST0320809
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