The AAA (ATPase associated with various cellular activities) ATPase, p97, is a hexameric protein of chaperone-like function, which has been reported to interact with a number of proteins of seemingly unrelated functions. For the first time, we report a classification of these proteins and aim to elucidate any common structural or functional features they may share. The interactors are grouped into those containing ubiquitin regulatory X domains, which presumably bind to p97 in the same way as the p47 adaptor, and into non-ubiquitin regulatory X domain proteins of different functional subgroups that may employ a different mode of interaction (assuming they also bind directly to p97 and are not experimental artifacts). Future studies will show whether interacting proteins direct p97 to different cellular pathways or a common one and structural elucidation of these interactions will be crucial in understanding these underlying functions.
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November 2004
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Conference Article|
October 26 2004
p97 and close encounters of every kind: a brief review
I. Dreveny;
I. Dreveny
1
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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V.E. Pye;
V.E. Pye
1
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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F. Beuron;
F. Beuron
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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L.C. Briggs;
L.C. Briggs
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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R.L. Isaacson;
R.L. Isaacson
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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S.J. Matthews;
S.J. Matthews
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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C. McKeown;
C. McKeown
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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X. Yuan;
X. Yuan
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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X. Zhang;
X. Zhang
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
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P.S. Freemont
P.S. Freemont
2
1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London SW7 2AZ, U.K.
2To whom correspondence should be addressed (email p.freemont@imperial.ac.uk).
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Publisher: Portland Press Ltd
Received:
June 18 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (5): 715–720.
Article history
Received:
June 18 2004
Citation
I. Dreveny, V.E. Pye, F. Beuron, L.C. Briggs, R.L. Isaacson, S.J. Matthews, C. McKeown, X. Yuan, X. Zhang, P.S. Freemont; p97 and close encounters of every kind: a brief review. Biochem Soc Trans 1 November 2004; 32 (5): 715–720. doi: https://doi.org/10.1042/BST0320715
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