IFT (intraflagellar transport) assembles and maintains sensory cilia on the dendritic endings of chemosensory neurons within the nematode Caenorhabditis elegans. During IFT, macromolecular protein complexes called IFT particles (which carry ciliary precursors) are moved from the base of the sensory cilium to its distal tip by anterograde IFT motors (kinesin-II and Osm-3 kinesin) and back to the base by retrograde IFT-dynein [Rosenbaum and Witman (2002) Nat. Rev. Mol. Cell Biol. 3, 813–825; Scholey (2003) Annu. Rev. Cell Dev. Biol. 19, 423–443; and Snell, Pan and Wang (2004) Cell 117, 693–697]. In the present study, we describe the protein machinery of IFT in C. elegans, which we have analysed using time-lapse fluorescence microscopy of green fluorescent protein-fusion proteins in concert with ciliary mutants.
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Conference Article|
October 26 2004
Intraflagellar transport motors in Caenorhabditis elegans neurons
J.M. Scholey;
J.M. Scholey
1
1Section of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, CA 95616, U.S.A.
1To whom correspondence should be addressed (email jmscholey@ucdavis.edu).
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G. Ou;
G. Ou
1Section of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, CA 95616, U.S.A.
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J. Snow;
J. Snow
1Section of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, CA 95616, U.S.A.
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A. Gunnarson
A. Gunnarson
1Section of Molecular and Cellular Biology, Center for Genetics and Development, University of California, Davis, CA 95616, U.S.A.
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Publisher: Portland Press Ltd
Received:
June 14 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (5): 682–684.
Article history
Received:
June 14 2004
Citation
J.M. Scholey, G. Ou, J. Snow, A. Gunnarson; Intraflagellar transport motors in Caenorhabditis elegans neurons. Biochem Soc Trans 1 November 2004; 32 (5): 682–684. doi: https://doi.org/10.1042/BST0320682
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