The TOR (target of rapamycin) pathway is a phylogenetically conserved transduction system in eukaryotes linking the energy status of the cell to the protein synthesis apparatus and to cell growth. The TOR protein is specifically inhibited by a rapamycin–FKBP12 complex (where FKBP stands for FK506-binding protein) in yeast and animal cells. Whereas plants appear insensitive to rapamycin, Arabidopsis thaliana harbours a single TOR gene, which is essential for embryonic development. It was found that the product of this gene was capable of binding to rapamycin and yeast FKBP12. In-frame fusion with a GUS reporter gene shows that the TOR protein is produced essentially in proliferating zones, whereas the TOR mRNA can be detected in all organs suggesting a translational regulation of TOR. Phenotypic analysis of Arabidopsis TOR mutants indicates that the plant TOR pathway fulfils the same role in controlling cell growth as its other eukaryotic counterparts.
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August 2004
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Conference Article|
August 01 2004
Plant growth: the translational connection
C. Robaglia;
C. Robaglia
1
*Laboratoire de Génétique et Biophysique des Plantes, Département d'Ecophysiologie Végétale et Microbiologie, UMR 6191 CNRS-CEA-Université de la Méditerranée, Luminy, Marseille, France
1To whom correspondence should be addressed (email ROBAGLIA@dsvsud.cea.fr).
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B. Menand;
B. Menand
†Department of Cell and Molecular Biology, John Innes Center, Norwich, U.K.
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Y. Lei;
Y. Lei
*Laboratoire de Génétique et Biophysique des Plantes, Département d'Ecophysiologie Végétale et Microbiologie, UMR 6191 CNRS-CEA-Université de la Méditerranée, Luminy, Marseille, France
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R. Sormani;
R. Sormani
*Laboratoire de Génétique et Biophysique des Plantes, Département d'Ecophysiologie Végétale et Microbiologie, UMR 6191 CNRS-CEA-Université de la Méditerranée, Luminy, Marseille, France
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M. Nicolaï;
M. Nicolaï
*Laboratoire de Génétique et Biophysique des Plantes, Département d'Ecophysiologie Végétale et Microbiologie, UMR 6191 CNRS-CEA-Université de la Méditerranée, Luminy, Marseille, France
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C. Gery;
C. Gery
‡Unité de Génétique, INRA, Versailles, France
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E. Teoulé;
E. Teoulé
‡Unité de Génétique, INRA, Versailles, France
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D. Deprost;
D. Deprost
§Laboratoire de Nutrition Azotée des Plantes, INRA, Versailles, France
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C. Meyer
C. Meyer
§Laboratoire de Nutrition Azotée des Plantes, INRA, Versailles, France
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Publisher: Portland Press Ltd
Received:
April 27 2004
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 The Biochemical Society
2004
Biochem Soc Trans (2004) 32 (4): 581–584.
Article history
Received:
April 27 2004
Citation
C. Robaglia, B. Menand, Y. Lei, R. Sormani, M. Nicolaï, C. Gery, E. Teoulé, D. Deprost, C. Meyer; Plant growth: the translational connection. Biochem Soc Trans 1 August 2004; 32 (4): 581–584. doi: https://doi.org/10.1042/BST0320581
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