Human granulocytes clearly play an important role in host defence against invading organisms, however they have also been implicated in the pathogenesis and progression of many chronic inflammatory diseases. In addition, these cells have been paramount in gaining a better understanding of many key-signalling pathways regulating fundamental biological processes. Since granulocytes are terminally differentiated and undergo relatively rapid constitutive apoptosis it has been difficult to manipulate intracellular events by transfection or transduction procedures. It has been shown in recent years that the HIV-TAT protein transduction system can be successfully used in granulocytes to manipulate key signalling mechanisms regulating functional responsiveness and survival. In this paper, we review recent literature highlighting important developments using this system in isolated human granulocytes and in inflammatory process in vivo where these cells play a prominent role.
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Conference Article|
June 01 2004
Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods
A.G. Rossi;
A.G. Rossi
1
MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U.K.
1To whom correspondence should be addressed (email a.g.rossi@ed.ac.uk).
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C. Ward;
C. Ward
MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U.K.
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I. Dransfield
I. Dransfield
MRC Centre for Inflammation Research, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U.K.
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (3): 452–455.
Citation
A.G. Rossi, C. Ward, I. Dransfield; Getting to grips with the granulocyte: manipulation of granulocyte behaviour and apoptosis by protein transduction methods. Biochem Soc Trans 1 June 2004; 32 (3): 452–455. doi: https://doi.org/10.1042/bst0320452
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