β-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. β-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which are dispersed by statins.

Keywords:
Alzheimer's disease, amyloidogenesis, cholesterol, glycosylation, lovastatin, proteolysis, β-secretase
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© 2004 Biochemical Society
2004
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