We have investigated serum chemokines for their suitability as markers of atherosclerosis development in apoE (apolipoprotein E)-deficient (−/−) mice. Female C3H apoE−/− and C57BL apoE−/− mice were fed on either diet W (Western diet; 6 weeks) or normal rodent diet (12 weeks). Serum lipids (0, 6 and 12 weeks) and terminal chemokine levels were measured using commercially available assays, whereas the lesion area was determined using Oil-Red O-stained aortic sections. Serum lipids were higher in C3H apoE−/− mice for both diets throughout the study; however, lesions were significantly larger in C57BL apoE−/− mice fed on either diet. Chemokine levels were significantly lower in C3H apoE−/− mice fed on the normal diet, but no difference was observed between the two groups fed on diet W. We conclude that serum chemokine levels are potential markers for atherosclerosis susceptibility in C3H and C57BL apoE−/− mice fed on a normal rodent diet.
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Conference Article|
February 01 2004
Circulating levels of the chemokines JE and KC in female C3H apolipoprotein-E-deficient and C57BL apolipoprotein-E-deficient mice as potential markers of atherosclerosis development
S.L. Parkin;
S.L. Parkin
*Biochemistry and Molecular Biology Department, Royal Free and University College Medical School, Royal Free Campus, London NW3 2PF, U.K.
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J.P. Pritchett;
J.P. Pritchett
†Atherosclerosis Department, GlaxoSmithKline, Stevenage SG1 2NY, U.K.
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D.C. Grimsditch;
D.C. Grimsditch
†Atherosclerosis Department, GlaxoSmithKline, Stevenage SG1 2NY, U.K.
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K.R. Bruckdorfer;
K.R. Bruckdorfer
*Biochemistry and Molecular Biology Department, Royal Free and University College Medical School, Royal Free Campus, London NW3 2PF, U.K.
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P.K. Sahota;
P.K. Sahota
‡Statistical Sciences Europe, GlaxoSmithKline, Harlow CM19 5AW, U.K.
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A. Lloyd;
A. Lloyd
‡Statistical Sciences Europe, GlaxoSmithKline, Harlow CM19 5AW, U.K.
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P. Overend;
P. Overend
‡Statistical Sciences Europe, GlaxoSmithKline, Harlow CM19 5AW, U.K.
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G.M. Benson
G.M. Benson
1
†Atherosclerosis Department, GlaxoSmithKline, Stevenage SG1 2NY, U.K.
1To whom correspondence should be addressed (e-mail g_martin_benson@gsk.com).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2004 Biochemical Society
2004
Biochem Soc Trans (2004) 32 (1): 128–130.
Citation
S.L. Parkin, J.P. Pritchett, D.C. Grimsditch, K.R. Bruckdorfer, P.K. Sahota, A. Lloyd, P. Overend, G.M. Benson; Circulating levels of the chemokines JE and KC in female C3H apolipoprotein-E-deficient and C57BL apolipoprotein-E-deficient mice as potential markers of atherosclerosis development. Biochem Soc Trans 1 February 2004; 32 (1): 128–130. doi: https://doi.org/10.1042/bst0320128
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