Various theories have been proposed to explain the hyperglycaemia-induced pathogenesis of vascular complications of diabetes, including detrimental effects of AGEs (advanced glycation end products) on vascular tissues. Increased formation of the very reactive dicarbonyl compound MGO (methylglyoxal), one of the side-products of glycolysis, and MGO-derived AGEs seem to be implicated in the development of diabetic vascular complications. Although the exact role of MGO and MGO adducts in the development of vascular complications is unknown, receptor-mediated activation of vascular cells by the MGO–arginine adduct hydroimidazolone, as well as intracellular modifications of protein by MGO, seem to be involved. The aim of this mini-review is to assess to what extent MGO is related to vascular complications in diabetes.
Skip Nav Destination
Article navigation
December 2003
- PDF Icon PDF LinkFront Matter
Conference Article|
December 01 2003
Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus
M. Bourajjaj;
M. Bourajjaj
*Department of Clinical Chemistry, Institute for Cardiovascular Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
†Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Search for other works by this author on:
C.D.A. Stehouwer;
C.D.A. Stehouwer
†Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Search for other works by this author on:
V.W.M. van Hinsbergh;
V.W.M. van Hinsbergh
‡Department of Physiology, Institute for Cardiovascular Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Search for other works by this author on:
C.G. Schalkwijk
C.G. Schalkwijk
1
*Department of Clinical Chemistry, Institute for Cardiovascular Research, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
1To whom correspondence should be addressed (e-mail c.schalkwijk@vumc.nl).
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (6): 1400–1402.
Citation
M. Bourajjaj, C.D.A. Stehouwer, V.W.M. van Hinsbergh, C.G. Schalkwijk; Role of methylglyoxal adducts in the development of vascular complications in diabetes mellitus. Biochem Soc Trans 1 December 2003; 31 (6): 1400–1402. doi: https://doi.org/10.1042/bst0311400
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.