FA (fatty acid) recycling in adipose tissue appears to be an important pathway for regulating FA release into the blood during fasting. Re-esterification requires G3P (glycerol 3-phosphate), which cannot be synthesized from glucose because glycolysis is much reduced under such circumstances. In addition, G3P can scarcely originate from glycerol since glycerol kinase has a very low activity in white adipose tissue. It was shown about 35 years ago that a metabolic pathway named glyceroneogenesis, which allows G3P synthesis from non-carbohydrate precursors like pyruvate, lactate or amino acids, is activated during fasting. The major enzyme in this pathway was shown to be PEPCK-C [cytosolic phosphoenolpyruvate carboxykinase (GTP); EC 4.1.1.32]. The present review analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C gene transcription and glyceroneogenesis and describes evidence for dysregulation of this pathway in type 2 diabetes.
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December 2003
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Conference Article|
December 01 2003
Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase
C. Forest;
C. Forest
1
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
1To whom correspondence should be addressed (e-mail claude.forest@biomedicale.univ-paris5.fr).
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J. Tordjman;
J. Tordjman
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
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M. Glorian;
M. Glorian
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
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E. Duplus;
E. Duplus
2
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
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G. Chauvet;
G. Chauvet
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
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J. Quette;
J. Quette
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
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E.G. Beale;
E.G. Beale
†Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, U.S.A.
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B. Antoine
B. Antoine
*UMR-S 530 Inserm-Université René Descartes, Centre Universitaire-U.F.R. Biomédicale, 45 rue des Saints-Pères, 75006, Paris, France
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (6): 1125–1129.
Citation
C. Forest, J. Tordjman, M. Glorian, E. Duplus, G. Chauvet, J. Quette, E.G. Beale, B. Antoine; Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase. Biochem Soc Trans 1 December 2003; 31 (6): 1125–1129. doi: https://doi.org/10.1042/bst0311125
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