Interestingly, there is a major difference in turnover rate between ornithine decarboxylases (ODCs) from various trypanosomatids. ODCs from Trypanosoma brucei and Leishmania donovani are both stable proteins, whereas ODC from Crithidia fasciculata is a metabolically unstable protein in the parasite. C. fasciculata ODC is also rapidly degraded in mammalian systems, whereas the closely related L. donovani ODC is not. The degradation of C. fasciculata ODC in the mammalian systems is shown to be dependent on a functional 26 S proteasome. However, in contrast to the degradation of mammalian ODC, the degradation of C. fasciculata ODC does not involve antizyme. Instead, it appears the degradation of C. fasciculata ODC may be associated with poly-ubiquitination of the enzyme.
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April 2003
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Conference Article|
April 01 2003
Turnover of trypanosomal ornithine decarboxylases
L. Persson;
L. Persson
1
Department of Physiological Sciences, Lund University, BMC F:13, S-221 84 Lund, Sweden
1To whom correspondence should be addressed (e-mail Lo.Persson@mphy.lu.se).
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A. Jeppsson;
A. Jeppsson
Department of Physiological Sciences, Lund University, BMC F:13, S-221 84 Lund, Sweden
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S. Nasizadeh
S. Nasizadeh
Department of Physiological Sciences, Lund University, BMC F:13, S-221 84 Lund, Sweden
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
Copyright 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (2): 411–414.
Citation
L. Persson, A. Jeppsson, S. Nasizadeh; Turnover of trypanosomal ornithine decarboxylases. Biochem Soc Trans 1 April 2003; 31 (2): 411–414. doi: https://doi.org/10.1042/bst0310411
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