We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.

Keywords:
activation function 2, ligand binding, steroid receptor, transcription factor
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Copyright 2003 Biochemical Society
2003
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