BRCA1 (breast-cancer susceptibility gene 1) is a tumour suppressor gene that is mutated in the germline of women with a genetic predisposition to breast and ovarian cancer. In this review, we examine the role played by BRCA1 in mediating the cellular response to stress. We review the role played by BRCA1 in detecting and signalling the presence of DNA damage, particularly double-strand DNA breaks, and look at the evidence to support a role for BRCA1 in regulating stress response pathways such as the c-Jun N-terminal kinase/stress-activated protein kinase pathway. In addition, we examine the role played by BRCA1 in mediating both cell-cycle arrest and apoptosis following different types of cellular insult, and how this may be modulated by the presence or absence of associated proteins such as p53. Finally, we explore the possibility that many of the functions associated with BRCA1 may be based on transcriptional regulation of key downstream genes that have been implicated in the regulation of these specific cellular pathways.
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February 2003
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Conference Article|
February 01 2003
Role played by BRCA1 in regulating the cellular response to stress
P.M. Gilmore;
P.M. Gilmore
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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J.E. Quinn;
J.E. Quinn
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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P.B. Mullan;
P.B. Mullan
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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H.N. Andrews;
H.N. Andrews
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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N. McCabe;
N. McCabe
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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M. Carty;
M. Carty
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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R.D. Kennedy;
R.D. Kennedy
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
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D.P. Harkin
D.P. Harkin
1
Cancer Research Centre, Department of Oncology, Queen's University Belfast, University Floor, Belfast City Hospital, Lisburn Road, Belfast BT9 7AB, U.K.
1To whom correspondence should be addressed (e-mail: d.harkin@qub.ac.uk).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
Copyright 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (1): 257–262.
Citation
P.M. Gilmore, J.E. Quinn, P.B. Mullan, H.N. Andrews, N. McCabe, M. Carty, R.D. Kennedy, D.P. Harkin; Role played by BRCA1 in regulating the cellular response to stress. Biochem Soc Trans 1 February 2003; 31 (1): 257–262. doi: https://doi.org/10.1042/bst0310257
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