Leptin regulates energy homoeostasis through central and peripheral mechanisms. Initial steps in leptin action include signalling through a cytokine-like receptor which activates the JAK/STAT pathway. We investigated whether the metabolic effects of leptin in muscle could be mediated by the AMP-activated protein kinase (AMP kinase). Through studies involving leptin injection intrahypothalamically or intravenously, as well as incubation of soleus muscle or cultured muscle cells with leptin, we determined that leptin stimulates fatty acid oxidation in skeletal muscle by activating AMP kinase. Leptin exerts this effect directly at the level of muscle and also through the hypothalamic sympathetic nervous system, specifically engaging α-adrenergic receptors in muscle. This represents a novel and important pathway mediating leptin's metabolic actions.
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February 2003
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Conference Article|
February 01 2003
Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle
Y. Minokoshi;
Y. Minokoshi
Division of Endocrinology, Diabetes and Metabolism, Research North 325E, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, MA 02215, U.S.A., and The Department of Medicine, Harvard Medical School, Boston, MA 02215, U.S.A.
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B.B. Kahn
B.B. Kahn
1
Division of Endocrinology, Diabetes and Metabolism, Research North 325E, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, MA 02215, U.S.A., and The Department of Medicine, Harvard Medical School, Boston, MA 02215, U.S.A.
1To whom correspondence should be addressed (e-mail bkahn@caregroup.harvard.edu).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
Copyright 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (1): 196–201.
Citation
Y. Minokoshi, B.B. Kahn; Role of AMP-activated protein kinase in leptin-induced fatty acid oxidation in muscle. Biochem Soc Trans 1 February 2003; 31 (1): 196–201. doi: https://doi.org/10.1042/bst0310196
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