Evidence is accumulating for roles of AMP-activated protein kinase (AMPK) in controlling glucose uptake, fatty acid oxidation and gene expression in skeletal muscle. Relatively little is known, however, about the control of expression of the AMPK subunit isoforms. Marked differences are noted in subunit expression as a function of muscle fibre type. Expression of the γ3 subunit isoform increases in fast-twitch red fibres of the rat in response to training. All subunit isoforms are expressed to a lesser extent in rats treated with propylthiouracil (PTU; an inhibitor of thyroid hormone synthesis) for 3 weeks compared with rats given excess thyroid hormones for 3 weeks. An approx. 2-fold increase in acetyl-CoA carboxylase was observed in gastrocnemius of hyperthyroid rats compared with experimentally hypothyroid rats. Thyroid state therefore appears to be one important factor controlling expression of these proteins in skeletal muscle.
Skip Nav Destination
Article navigation
February 2003
- PDF Icon PDF LinkFront Matter
Conference Article|
February 01 2003
Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle
W.W. Winder;
W.W. Winder
1
*Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A.
1To whom correspondence should be addressed (e-mail William_winder@byu.edu).
Search for other works by this author on:
D.G. Hardie;
D.G. Hardie
†Division of Molecular Physiology, Dundee University, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, Scotland, U.K.
Search for other works by this author on:
K.J. Mustard;
K.J. Mustard
†Division of Molecular Physiology, Dundee University, Wellcome Trust Biocentre, Dow Street, Dundee DD1 5EH, Scotland, U.K.
Search for other works by this author on:
L.J. Greenwood;
L.J. Greenwood
*Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A.
Search for other works by this author on:
B.E. Paxton;
B.E. Paxton
*Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A.
Search for other works by this author on:
S.H. Park;
S.H. Park
*Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A.
Search for other works by this author on:
D.S. Rubink;
D.S. Rubink
*Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A.
Search for other works by this author on:
E.B. Taylor
E.B. Taylor
*Department of Physiology and Developmental Biology, 545 WIDB, Brigham Young University, Provo, UT 84602, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8752
Print ISSN: 0300-5127
Copyright 2003 Biochemical Society
2003
Biochem Soc Trans (2003) 31 (1): 182–185.
Citation
W.W. Winder, D.G. Hardie, K.J. Mustard, L.J. Greenwood, B.E. Paxton, S.H. Park, D.S. Rubink, E.B. Taylor; Long-term regulation of AMP-activated protein kinase and acetyl-CoA carboxylase in skeletal muscle. Biochem Soc Trans 1 February 2003; 31 (1): 182–185. doi: https://doi.org/10.1042/bst0310182
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.