AMP-activated protein kinase, super metabolic regulator

Kemp, B.E.; Stapleton, D.; Campbell, D.J.; Chen, Z.-P.; Murthy, S.; Walter, M.; Gupta, A.; Adams, J.J.; Katsis, F.; van Denderen, B.; Jennings, I.G.; Iseli, T.; Michell, B.J.; Witters, L.A.

doi:10.1042/bst0310162

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Conference Article| February 01 2003

AMP-activated protein kinase, super metabolic regulator

B.E. Kemp;

B.E. Kemp ¹

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

1To whom correspondence should be addressed (e-mail kemp@ariel.unimelb.edu.au).

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D. Stapleton;

D. Stapleton

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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D.J. Campbell;

D.J. Campbell

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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Z.-P. Chen;

Z.-P. Chen

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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S. Murthy;

S. Murthy

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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M. Walter;

M. Walter

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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A. Gupta;

A. Gupta

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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J.J. Adams;

J.J. Adams

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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F. Katsis;

F. Katsis

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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B. van Denderen;

B. van Denderen

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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I.G. Jennings;

I.G. Jennings

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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T. Iseli;

T. Iseli

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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B.J. Michell;

B.J. Michell

*St. Vincent's Institute of Medical Research, and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Vic. 3065, Australia

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L.A. Witters

†Departments of Medicine and Biochemistry, Dartmouth Medical School, Hanover, NH, U.S.A.

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Author and article information

Publisher: Portland Press Ltd

Online ISSN: 1470-8752

Print ISSN: 0300-5127

2003

Biochem Soc Trans (2003) 31 (1): 162–168.

https://doi.org/10.1042/bst0310162

The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.

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