The phenotype of mitogen-activated protein kinase-activated protein kinase-2 (MK2) knockout mice revealed the essential role of this enzyme in post-transcriptional regulation of lipopolysaccharide-induced expression of cytokines such as tumour necrosis factor (TNF)-α, interleukin-6 and interferon-γ, at the level of mRNA stability and translation. In the case of TNF-α, this regulation depends on the AU-rich element in TNF-α mRNA. In addition to cytokine expression, MK2 is also essential for cell migration in vitro. Although the role of MK2 in cytokine expression depends mainly on catalytic activity, its role in cell migration is also dependent on a proline-rich N-terminal motif. However, the molecular mechanisms involved and the relevant protein targets for MK2 are not completely defined. Here we discuss the possible mechanisms by which two potential target proteins of MK2, small heat-shock protein 25/27 (Hsp25/27) and tristetraprolin, could contribute to our understanding of the above regulation.
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Conference Article|
November 01 2002
Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?
A. Kotlyarov;
A. Kotlyarov
1Medical School Hannover, Institute of Biochemistry, Carl-Neuberg-Strasse I, Hannover 30625, Germany
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M. Gaestel
M. Gaestel
1
1Medical School Hannover, Institute of Biochemistry, Carl-Neuberg-Strasse I, Hannover 30625, Germany
1To whom correspondence should be addressed (e-mail Gaestel.Matthias@mh-hannover.de)
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Publisher: Portland Press Ltd
Received:
June 07 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (6): 959–963.
Article history
Received:
June 07 2002
Citation
A. Kotlyarov, M. Gaestel; Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression?. Biochem Soc Trans 1 November 2002; 30 (6): 959–963. doi: https://doi.org/10.1042/bst0300959
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