The diagnostics industry is constantly under pressure to bring innovation quicker to market and so the impetus to speed up product-development cycle times becomes greater. There are a number of steps in the product-development cycle where the application of high-throughput screening can help. In the case of lateral-flow immunodiagnostics the selection of antibody reagents is paramount. In particular, rapid identification of antibody pairs that are able to ‘sandwich’ around the target antigen is required. One screen that has been applied successfully is the use of surface plasmon resonance biosensors like Biacore®. Using such a system one can evaluate over 400 antibody pairings in under 5 days. Conventional approaches to screen this number of antibody pairs would take many months. Other automated screening systems like DELFIA® can be used in processing the vast amount of tests required for clinical trials. In addition, the use of robotics to automate routine product testing can be used to shorten the product-development cycle.
Skip Nav Destination
Article navigation
August 2002
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
August 01 2002
High-throughput screening in the diagnostics industry
S. Wilson;
S. Wilson
1Unipath Ltd., Priory Business Park, Bedford MK44 3UP, U.K.
Search for other works by this author on:
S. Howell
S. Howell
1
1Unipath Ltd., Priory Business Park, Bedford MK44 3UP, U.K.
1E-mail steve.howell@unipath.com
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
April 09 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 794–797.
Article history
Received:
April 09 2002
Citation
S. Wilson, S. Howell; High-throughput screening in the diagnostics industry. Biochem Soc Trans 1 August 2002; 30 (4): 794–797. doi: https://doi.org/10.1042/bst0300794
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.