Duodenal cytochrome b (Dcytb) is a haem protein similar to the cytochrome b561 protein family. Dcytb is highly expressed in duodenal brush-border membrane and is implicated in dietary iron absorption by reducing dietary ferric iron to the ferrous form for transport via Nramp2/DCT1 (divalent-cation transporter 1)/DMT1 (divalent metal-transporter 1). The protein is expressed in other tissues and may account for ferric reductase activity at other sites in the body.

Keywords:
duodenal cytochrome b, intestine, neutrophil, Dcytb, duodenal cytochrome b, DCT, divalent-cation transporter
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© 2002 Biochemical Society
2002
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