The denitrification pathway has been studied in the hyperthermophilic archaeon Pyrobaculum aerophilum. In contrast with Gram-negative bacteria, all four denitrification enzymes are membrane-bound. P. aerophilum is also the only denitrifyer identified so far in which menaquinol is the electron donor to all four denitrification reductases. The NO reductase (NOR) of P. aerophilum belongs to the superfamily of haem-copper oxidases and is of the qNOR (quinol-dependent) type. Three types of NOR have been purified so far: cNOR (cytochrome c/pseudoazurin-dependent), qNOR and qCuANOR (qNOR that contains CuA at the electron entry site). It is proposed that the NORs and the various cytochrome oxidases have evolved by modular evolution, in view of the structure of their electron donor sites. qNOR is further proposed to be the ancestor of all NORs and cytochrome oxidases belonging to the superfamily of haem-copper oxidases.
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Conference Article|
August 01 2002
Comparison between the nitric oxide reductase family and its aerobic relatives, the cytochrome oxidases
S. de Vries;
S. de Vries
1
*Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
1To whom correspondence should be addressed (e-mail s.devries@tnw.tudelf.nl)
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I. Schröder
I. Schröder
†Department of Microbiology and Molecular Genetics, University of California, Los Angeles, CA, U.S.A.
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Publisher: Portland Press Ltd
Received:
March 13 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 662–667.
Article history
Received:
March 13 2002
Citation
S. de Vries, I. Schröder; Comparison between the nitric oxide reductase family and its aerobic relatives, the cytochrome oxidases. Biochem Soc Trans 1 August 2002; 30 (4): 662–667. doi: https://doi.org/10.1042/bst0300662
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