The best known family B, or Type II, G-protein-coupled receptors (GPCRs) recognize peptides as ligands. The receptors for corticotrophin-releasing factor, parathyroid hormone and secretin typify this group. However, there are only 15 such GPCRs. Many other receptors share sequence homology and have been assigned to this family. The ten ‘Frizzled’ and one ‘Smoothened’ receptors show the lowest sequence homology and are not necessarily G-protein coupled. Drosophila genetics have enabled our understanding of their biology. In contrast, relatively little is known about the largest group with family B, the 33 ‘large amino termini’ or large N-terminal family B seven-transmembrane (LNB 7TM) receptors. This review highlights the similarities found between family B receptors and provides a classification of LNB 7TM receptors.
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Conference Article|
August 01 2002
Bioinformatics and type II G-protein-coupled receptors
S. M. Foord;
S. M. Foord
1
1Bioinformatics, GlaxoSmithKline, Stevenage, Herts. SG1 2NY, U.K.
1To whom correspondence should be addressed (e-mail smf3746@ggr.co.uk)
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S. Jupe;
S. Jupe
1Bioinformatics, GlaxoSmithKline, Stevenage, Herts. SG1 2NY, U.K.
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J. Holbrook
J. Holbrook
1Bioinformatics, GlaxoSmithKline, Stevenage, Herts. SG1 2NY, U.K.
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Publisher: Portland Press Ltd
Received:
March 11 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 473–479.
Article history
Received:
March 11 2002
Citation
S. M. Foord, S. Jupe, J. Holbrook; Bioinformatics and type II G-protein-coupled receptors. Biochem Soc Trans 1 August 2002; 30 (4): 473–479. doi: https://doi.org/10.1042/bst0300473
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