The receptor for calcitonin-gene-related peptide (CGRP) is a heterodimer formed by calcitonin-receptor-like receptor (CRLR), a type II (family B) G-protein-coupled receptor, and receptor-activity-modifying protein 1 (RAMP1), a single-membrane-pass protein. It is likely that the first seven or so amino acids of CGRP (which form a disulphide-bonded loop) interact with the transmembrane domain of CRLR to cause receptor activation. The rest of the CGRP molecule falls into three domains. Residues 28–37 and 8–18 are normally required for high-affinity binding, while residues 19–27 form a hinge region. The 28–37 region is almost certainly in direct contact with the receptor; 8–18 may make additional receptor contacts or may stabilize an appropriate conformation of 28–37. It is likely that these regions of CGRP interact both with CRLR and with the extracellular domain of RAMP1.
Skip Nav Destination
Article navigation
August 2002
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
Conference Article|
August 01 2002
Interaction of calcitonin-gene-related peptide with its receptors
A. C. Conner;
A. C. Conner
*Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, U.K.
Search for other works by this author on:
D. L. Hay;
D. L. Hay
†Imperial College School of Medicine, Du Cane Road, London W12 0NN, U.K.
Search for other works by this author on:
S. G. Howitt;
S. G. Howitt
*Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, U.K.
Search for other works by this author on:
K. Kilk;
K. Kilk
‡The Arrhenius Laboratory, Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
Search for other works by this author on:
Ü. Langel;
Ü. Langel
‡The Arrhenius Laboratory, Department of Neurochemistry and Neurotoxicology, Stockholm University, Stockholm, Sweden
Search for other works by this author on:
M. Wheatley;
M. Wheatley
§School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Search for other works by this author on:
D. M. Smith;
D. M. Smith
||CVGI Group, AstraZeneca, Alderley Edge, Cheshire SK10 4TG, U.K.
Search for other works by this author on:
D. R. Poyner
D. R. Poyner
1
*Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, U.K.
1To whom correspondence should be addressed (e-mail d.r.poyner@aston.ac.uk)
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
March 06 2002
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© 2002 Biochemical Society
2002
Biochem Soc Trans (2002) 30 (4): 451–455.
Article history
Received:
March 06 2002
Citation
A. C. Conner, D. L. Hay, S. G. Howitt, K. Kilk, Ü. Langel, M. Wheatley, D. M. Smith, D. R. Poyner; Interaction of calcitonin-gene-related peptide with its receptors. Biochem Soc Trans 1 August 2002; 30 (4): 451–455. doi: https://doi.org/10.1042/bst0300451
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.